IMPORTANT DATABASES AND TOOLS TO IDENTIFY PROMISING DRUG TARGETS BY SUBTRACTIVE GENOMICS APPROACH – A REVIEW

Identification of putative drug targets of Listeria monocytogenes F2365 by subtractive genomics approach

Article info: Received: 28 November 2012 Accepted: 1 March 2013 ABSTRACT The prolonged and uncontrolled use of antibiotics in treatment against many pathogens causes the multiple drug resistance. The drug resistance of Listeria monocytogenes F2365 has been evolved, which cause a major disease listeriosis. The drug dose limit against that pathogen was also increased for currently prescribed anti...

Identification of membrane associated drug targets in Borrelia burgdorferi ZS7- subtractive genomics approach

Lyme disease is an infectious disease caused by a spirochete Borrelia burgdorferi ZS7. This spirochete is most often spread by ticks. Single antibiotic therapy is sufficient for containment of the early stage progression of the disease but combinational therapy is more preferred in later stages. Research is in progress for the development of drugs against the pathogen, but till date no vaccines...

Subtractive Genomics Approach for Insilico Identification and Characterization of Novel Membrane Associated Drug Targets Treponemapallidum Subspecies Pallidum Ss14

In silico subtractive/differential genome analysis is a powerful approach for identifying genus or species-specific genes, or groups of genes that are responsible for a unique phenotype. Subtractive genomic approach is one of the most useful strategies helpful in identification of potential drug targets. Availability of genome sequences of pathogens has provided a tremendous amount of informati...

Carbon Nanotubes: a Promising Approach for Drug Delivery

Carbon Nanotubes: a Promising Approach for Drug Delivery